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REVIEW article

Front. Med.
Sec. Nephrology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1428995

PTEN in kidney diseases: a potential therapeutic target in preventing AKI-to-CKD transition

Provisionally accepted
Jiali Wang Jiali Wang *Fangfang Cao Fangfang Cao Yuanyuan Li Yuanyuan Li Ting Peng Ting Peng Yuanmei Li Yuanmei Li Lihua Yang Lihua Yang Lanping Hu Lanping Hu Han Zhang Han Zhang
  • Mianyang Central Hospital, Mianyang, China

The final, formatted version of the article will be published soon.

    Renal fibrosis, a critical factor in the development of chronic kidney disease (CKD), is predominantly initiated by acute kidney injury (AKI) and subsequent maladaptive repair resulting from pharmacological or pathological stimuli. Phosphatase and tensin homolog (PTEN), also known as phosphatase and tensin-associated phosphatase, plays a pivotal role in regulating the physiological behavior of renal tubular epithelial cells, glomeruli, and renal interstitial cells, thereby preserving the homeostasis of renal structure and function. It significantly impacts cell proliferation, apoptosis, fibrosis, and mitochondrial energy metabolism during AKI-to-CKD transition. Despite gradual elucidation of PTEN's involvement in various kidney injuries, its specific role in AKI and maladaptive repair after injury remains unclear.This review endeavors to delineate the multifaceted role of PTEN in renal pathology during AKI and CKD progression along with its underlying mechanisms, emphasizing its influence on oxidative stress, autophagy, non-coding RNA-mediated recruitment and activation of immune cells as well as renal fibrosis. Furthermore, we summarize prospective therapeutic targeting strategies for AKI and CKD-treatment related diseases through modulation of PTEN.

    Keywords: CKD, Pten, AKI, AKI-toCKD, Kidney

    Received: 07 May 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Wang, Cao, Li, Peng, Li, Yang, Hu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiali Wang, Mianyang Central Hospital, Mianyang, China

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