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ORIGINAL RESEARCH article

Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1428593
This article is part of the Research Topic Endocrinology, Lipids, and Disease: Unraveling the Links View all articles

Correlation between Ratio of Fasting Blood Glucose to High Density Lipoprotein Cholesterol in Serum and Non-alcoholic Fatty Liver Disease in American Adults: A Population based Analysis

Provisionally accepted
Xianjing Jin Xianjing Jin 1*Jing Xu Jing Xu 2*Xiaochun Weng Xiaochun Weng 2*
  • 1 Wenzhou Yongjia County Traditional Chinese Medicine Hospital, Wenzhou, Zhejiang Province, China
  • 2 Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China

The final, formatted version of the article will be published soon.

    Background: Based on previous research, elevated fasting blood glucose (FBG) and decreased high-density lipoprotein cholesterol (HDL-C) levels are associated with non-alcoholic fatty liver disease (NAFLD). It is hypothesized that the prevalence of NAFLD may be proportional to the FBG-to-HDL-C ratio (GHR).: In this study, 3842 participants from the National Health and Nutrition Examination Survey (NHANES) (2013-2020) were investigated. Liver steatosis was assessed using vibrationcontrolled transient elastography (VCTE). NAFLD was defined as controlled attenuation parameter (CAP) ≥ 288 dB/m.Results: After adjusting for race, gender, age, diabetes, BMI, moderate activities, uric acid, albumin, ALT, GGT, ALP, total bilirubin and creatinine, multiple logistic regression analysis indicated a positive correlation between GHR and the prevalence of NAFLD (OR=1.22, 95% CI=1.17-1.28).Additionally, multiple linear regression analysis showed a positive correlation between GHR and the severity of liver steatosis according to CAP values (β = 4.97, 95% CI: 4.28, 5.66). According to the subgroup analysis, the correlation was stronger in other race, participants at the age < 50 years old and those with non-diabetes. In this study, a non-linear relationship and saturation effect between GHR and the prevalence of NAFLD was also revealed, characterized by an inverted L-shaped curve, with an inflection point of 7.443. Finally, the receiver operating characteristic (ROC) analysis suggested that the area under the curve (AUC) of GHR (AUC=0.731) significantly exceeded that of FBG and HDL-C.Elevated GHR levels are independently associated with the severity of liver steatosis and the increased prevalence of NAFLD in American adults.

    Keywords: Fasting blood glucose, Fatty Liver, Obesity, diabetes, Dyslipidemia

    Received: 06 May 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Jin, Xu and Weng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xianjing Jin, Wenzhou Yongjia County Traditional Chinese Medicine Hospital, Wenzhou, Zhejiang Province, China
    Jing Xu, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
    Xiaochun Weng, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China

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