Wenxiong Xu
Qiumin Luo
Chan Xie
Liang Peng
*The final, formatted version of the article will be published soon.
CASE REPORT article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1427043
This article is part of the Research Topic Chronic Hepatitis B Management: Current Status and Future Directions View all 5 articles
Case report: cccDNA and pgRNA remain positive in liver tissue in a chronic hepatitis B patient with functional cure
Provisionally accepted- Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Hepatitis B surface antigen (HBsAg) seroclearance is recommended as the ideal endpoint for nucleos(t)ide analogues (NAs) treatment. Functional cure of chronic hepatitis B (CHB) is defined as undetectable serum hepatitis B virus (HBV) deoxyribonucleic acid and serum HBsAg. We report a functional cure case of CHB with hepatocellular carcinoma (HCC) family history after long-term NAs therapy. Both HBV covalently closed circular deoxyribonucleic acid (cccDNA) and pregenomic ribonucleic acid (pgRNA) are remaining positive in liver tissue of the case, indicating that sterilizing cure is not achieved, although functional cure has been achieved for over seven years. This case highlights the importance of active surveillance of HBV cccDNA and pgRNA for sterilizing cure and risk of HCC.
Keywords: Hepatitis B surface antigen, Covalently closed circular deoxyribonucleic acid, pregenomic ribonucleic acid, functional cure, Chronic hepatitis B
Received: 02 May 2024; Accepted: 11 Oct 2024.
Copyright: © 2024 Xu, Luo, Zhang, Xie and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liang Peng, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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