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ORIGINAL RESEARCH article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1422267

Genetic and causal relationship between chronic gastrointestinal diseases and erectile dysfunction: A Mendelian randomization study

Provisionally accepted
Xiaoyan Zeng Xiaoyan Zeng 1Li Tong Li Tong 2*
  • 1 Xiaoyan Zeng, Xining, China
  • 2 Qinghai University, Xining, Qinghai Province, China

The final, formatted version of the article will be published soon.

    Studies based on observations have indicated potential associations between chronic gastrointestinal diseases and an increased risk of erectile dysfunction (ED). However, the causality of these connections remains ambiguous.Summary data for chronic gastrointestinal diseases were extracted from public data. Summary data on ED were extracted from three distinct sources. The genetic correlations between chronic gastrointestinal diseases and ED were explored using linkage disequilibrium score regression (LDSC). The causal associations between chronic gastrointestinal diseases and ED were evaluated using Mendelian randomization (MR) analysis, followed by a meta-analysis to determine the ultimate causal effect.The LDSC results suggested significant genetic correlations between Crohn's disease (CD) and ED. Inflammatory bowel disease (IBD), ulcerative colitis (UC), and liver cirrhosis (LC) were found to have potential genetic correlations with ED. The combined multiple MR results indicate that IBD and CD have significant causal relationships with ED, while colorectal cancer (CRC) may have a potential causal effect on ED.This research provided evidence supporting a causal association between IBD, CD, CRC, and ED. The impact of chronic gastrointestinal diseases on ED warrants greater attention in clinical practice.

    Keywords: Mendelian randomization, Chronic gastrointestinal diseases, Erectile Dysfunction, inflammatory bowel disease, colorectal cancer

    Received: 23 Apr 2024; Accepted: 17 Jul 2024.

    Copyright: © 2024 Zeng and Tong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Li Tong, Qinghai University, Xining, 810016, Qinghai Province, China

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