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ORIGINAL RESEARCH article

Front. Med.
Sec. Precision Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1418996
This article is part of the Research Topic Cluster-based Intelligent Recommendation System for Hybrid Healthcare Units View all 19 articles

Comparative Meta-Analysis of Hemodialysis and Peritoneal Dialysis for End-Stage Diabetic Nephropathy: Insights from China

Provisionally accepted
Chieh-Lun Yang Chieh-Lun Yang 1Yen-Jen Chen Yen-Jen Chen 1Hsiung-Ying Huang Hsiung-Ying Huang 1Qiong Cheng Qiong Cheng 1Wei Chen Wei Chen 1Wenhsing Yang Wenhsing Yang 2*
  • 1 Xiamen Chang Gung Hospital, Xiamen, Fujian Province, China
  • 2 Huaqiao University, Quanzhou, China

The final, formatted version of the article will be published soon.

    The study aimed to compare the efficacy and safety of hemodialysis and peritoneal Dialysis in treating end-stage diabetic nephropathy (DN). Databases including China HowNet, VIP, Wanfang, China Biomedical Literature, PubMed, Cochrane, and EMBASE were searched from inception to January 2019 to identify relevant studies. Data extraction and meta-analysis were performed using Revman 5.3 software. Outcomes assessed included protection of residual renal function, reduced bleeding events, maintained hemoglobin levels, and 36-month survival rates. A total of 16 studies involving 1122 patients were analyzed. Meta-analysis indicated that peritoneal Dialysis was superior to hemodialysis in preserving residual renal function (MD = 315.37, 95% CI 212.77-417.97, P < 0.001) and reducing bleeding events (RR = 0.61, 95% CI 0.41-0.99, P = 0.01), whereas hemodialysis was better at maintaining hemoglobin levels (MD = -1.67, 95% CI -3.18 -(-0.17), P = 0.03). The two treatments had no significant difference in 36-month survival rates (P = 0.53). In conclusion, peritoneal Dialysis appears more effective in preserving residual renal function and reducing bleeding events, while hemodialysis may better maintain hemoglobin levels.Survival rates at 36 months did not differ significantly between the two methods.

    Keywords: diabetic nephropathy, Peritoneal Dialysis, hemodialysis, Hemoglobin, Meta-analysis

    Received: 17 Apr 2024; Accepted: 04 Jul 2024.

    Copyright: © 2024 Yang, Chen, Huang, Cheng, Chen and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wenhsing Yang, Huaqiao University, Quanzhou, China

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