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CASE REPORT article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1418228

Case Report: Squamous cell carcinoma in situ of the cornea without involvement of the limbus and conjunctiva

Provisionally accepted
Ji Kyu Yun Ji Kyu Yun 1Young Joon Ryu Young Joon Ryu 1Yong Woo Lee Yong Woo Lee 1,2*
  • 1 Kangwon National University Hospital, Chuncheon, Republic of Korea
  • 2 Kangwon National University, Chuncheon, Gangwon, Republic of Korea

The final, formatted version of the article will be published soon.

    Isolated corneal squamous cell carcinoma without conjunctiva and limbus involvement is rare. We report a case of isolated squamous cell carcinoma in situ of the cornea. A 67-year-old male presented with visual disturbance in the left eye (visual acuity, 0.5), with a lesion isolated to the cornea. After an initial diagnosis of keratitis, he was lost to follow-up for 15 months. He subsequently returned for re-evaluation by a corneal specialist owing to progressive visual impairment in the left eye (visual acuity, 0.2). A left scrape biopsy and histopathological examination revealed squamous cell carcinoma in situ. No systemic evaluation findings of lymphadenopathy or metastasis were observed. Following removal of the residual mass from the cornea, conjunctival tissue samples, including the limbus, were collected for histopathological examination, with negative findings. No recurrence was observed at 15 months postoperatively. Isolated corneal squamous cell carcinoma in situ can be misdiagnosed as simple corneal opacity or keratitis during clinical examination. This condition should be considered in patients with unresponsive keratitis or corneal opacities.

    Keywords: Cornea, Ocular surface squamous neoplasia, Squamous cell carcinoma, Isolated, without limbal involvement

    Received: 19 Apr 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Yun, Ryu and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yong Woo Lee, Kangwon National University Hospital, Chuncheon, Republic of Korea

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