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ORIGINAL RESEARCH article

Front. Med.
Sec. Translational Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1417920

Efficacy of Autologous Micrografts Technology: a Promising Approach for Chronic Wound Healing and Tissue Regeneration -A Pilot Study

Provisionally accepted
Elisabetta Baglioni Elisabetta Baglioni 1Franco Perego Franco Perego 2Elisa Paolin Elisa Paolin 3,4*Alberto Abate Alberto Abate 5Tommaso Pusceddu Tommaso Pusceddu 6Barbara Zavan Barbara Zavan 6Maria A. Bocchiotti Maria A. Bocchiotti 1
  • 1 Department of Plastic Surgery, University of Turin, Torino, Italy
  • 2 Plastic Surgery Unit, Department of Neuroscience, School of Medicine and Surgery, University of Padua, Padua, Italy
  • 3 Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Lombardy, Italy
  • 4 Other, Candiolo, Italy
  • 5 San Martino Hospital (IRCCS), Genova, Liguria, Italy
  • 6 Department of Translational Medicine, University of Ferrara, Ferrara, Emilia-Romagna, Italy

The final, formatted version of the article will be published soon.

    This study explores the efficacy of Autologous Micrografts Technology (AMG) in treating chronic wounds refractory to traditional therapies. AMGs, derived from adipose tissue or dermis using a mechanical fragmentation process, were applied to patients with post-surgical dehiscence. A comprehensive evaluation of wound healing outcomes, including surface area reduction and complete healing, was conducted over a 90-day follow-up period. Additionally, the study investigated the cellular antioxidant activity of AMG solutions and characterized the exosomes obtained through mechanical disaggregation. Results indicate significant improvements (p<0,05) in wound healing, with 91.66% of patients showing at least a 50% reduction in lesion size and 75% achieving complete healing by day 90. Notably, AMG technology demonstrated immediate efficacy with fat-only application, while combined dermis and fat micrografts showed longer-term benefits, particularly in chronic wounds. The study also elucidated the mechanism of action of AMGs, highlighting their role in enhancing cellular antioxidant activity and exosome-mediated tissue regeneration. Overall, these findings underscore the promising potential of AMG technology as a versatile and effective treatment option for chronic wounds, warranting further investigation into its mechanisms and clinical applications.

    Keywords: micrografts1, regenerative medicine2, chronic wounds3, exosomes4, Antioxidant activity5

    Received: 15 Apr 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Baglioni, Perego, Paolin, Abate, Pusceddu, Zavan and Bocchiotti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Elisa Paolin, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Lombardy, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.