Dongmei Han
1,2
Tianbao Sun
1,2*
Han Li
1,2*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Med.
Sec. Nephrology
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1416021
A Study on the Correlation between Hyperuricemia and TG/HDLc Ratio in the Naxi ethnic group at High-Altitude Regions of Yunnan
Provisionally accepted- 1 Shanghai First Rehabilitation Hospital, Shanghai, China
- 2 School of Medicine, Tongji University, Shanghai, Shanghai Municipality, China
- 3 Other, Lijiang,Yunnan, China
The aim of this study is to explore the risk factors for hyperuricemia (HUA) in the Naxi ethnic population residing in high-altitude areas of Yunnan, China, and assess the clinical value of the triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c) as a diagnostic marker.In this cross-sectional study, clinical data were collected from the health checkup population in the People's Hospital of Yulong Naxi Autonomous County, Yunnan Province, from January 2021 to January 2023. Participants were divided into quartiles based on TG/HDL-c ratio (Q1, Q2, Q3, Q4) for group analysis using chi-square tests, t-tests, and rank sum tests. Logistic regression analysis and linear regression models were employed to further investigate the correlation between hyperuricemia prevalence and TG/HDL-c ratio in this high-altitude Naxi population.Results: A total of 714 participants with health checkup were included in the study ,the average age was 41.21±11.69 years, of which 61.5% were male and 38.5% were female. The mean uric acid level was 388.51±99.24. After correcting for confounding factors, TG/HDL-c, serum creatinine (Scr), blood urea nitrogen (BUN), TG, HDL-c, red blood cells (RBC), and hemoglobin (Hb) showed a positive correlation with blood uric acid. Further analysis involved categorizing the TG/HDL-c ratio from a continuous variable to a categorical variable using quartiles. The fully adjusted model showed consistent results with the trend observed in the continuous variable analysis when considering the TG/HDL-c ratio as a categorical variable. Additionally, in all unadjusted and adjusted models, the serum uric acid (SUA) levels in the high TG/HDL-c ratio group were significantly higher than those in the low TG/HDL-c ratio group (trend P < 0.001). Further linear relationship analysis indicated that after adjusting for covariates, there was an approximate linear relationship between TG/HDL-c and SUA levels, with a coefficient (β) of 5.421.The prevalence of hyperuricemia is high in high-altitude areas of Yunnan, showing a nearly linear positive correlation with the TG/HDL-c ratio. Monitoring TG/HDL-c levels may benefit patients with hyperuricemia.
Keywords: high altitude, Hyperuricemia, Triglycerides, High-density lipoprotein cholesterol, serum uric
Received: 11 Apr 2024; Accepted: 24 Jul 2024.
Copyright: © 2024 Han, Yao, Sun, Wang, He and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tianbao Sun, Shanghai First Rehabilitation Hospital, Shanghai, China
Han Li, Shanghai First Rehabilitation Hospital, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.