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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1415425

Effect of Propofol Versus Midazolam on Short-Term Outcomes in Patients with Sepsis-associated Acute Kidney Injury

Provisionally accepted
Yuanjie Li Yuanjie Li 1Taipu Guo Taipu Guo 1Zhenkun Yang Zhenkun Yang 1Rui Zhang Rui Zhang 1Zhi Wang Zhi Wang 2Yize LI Yize LI 1*
  • 1 Tianjin Medical University General Hospital, Tianjin, China
  • 2 Ordos Central Hospital, Dongsheng, Inner Mongolia, China

The final, formatted version of the article will be published soon.

    Background: Propofol and midazolam are commonly used sedative drugs in mechanically ventilated patients in the Intensive Care Unit (ICU). However, there is still a lack of relevant studies exploring the influence of midazolam and propofol on the prognosis of patients with Sepsis-associated Acute Kidney Injury (S-AKI).A statistical analysis was conducted on 3745 patients with S-AKI in the Medical Information Mart for Intensive Care IV database. The patients' baseline characteristics were grouped based on the use of either propofol or midazolam as sedatives. Cox proportional hazards models, logistic regression models, and subgroup analyses were used to compare the effects of propofol and midazolam on the short-term prognosis of S-AKI patients, including 30day mortality, ICU mortality, and duration of mechanical ventilation.In the statistical analysis, a total of 3745 patients were included, with 649 patients using midazolam and 3096 patients using propofol. In terms of the 30-day mortality, compared to patients using midazolam, S-AKI patients using propofol had a lower ICU mortality (hazard ratio = 0.62, 95% confidence interval: 0.52-0.74, P < 0.001), lower 30-day mortality (hazard ratio = 0.56, 95% confidence interval: 0.47-0.67, P < 0.001), and shorter mechanical ventilation time (odds ratio = 0.72, 95% confidence interval: 0.59-0.88, P < 0.001). Kaplan-Meier curves showed lower survival probabilities in the midazolam group (P < 0.001). Subgroup analyses showed that propofol was strongly protective of short-term prognosis in older, male, smaller SOFA score CCI score, no heart failure, and comorbid chronic kidney disease patients with S-AKI.Compared to midazolam, propofol was considered a protective factor for short-term mortality risk and ICU mortality risk in S-AKI patients. Additionally, S-AKI patients using propofol had a lower risk of requiring prolonged mechanical ventilation. Overall, propofol may be more beneficial for the short-term prognosis of S-AKI patients compared to midazolam.

    Keywords: MIMIC-IV, Sepsis-associated acute kidney injury, Propofol, Midazolam, Mortality

    Received: 17 Apr 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Li, Guo, Yang, Zhang, Wang and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yize LI, Tianjin Medical University General Hospital, Tianjin, 300052, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.