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CASE REPORT article

Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1413561

mNGS-Identified Cellulitis Due to Quinolone-Resistant Edwardsiella tarda: A Case Report

Provisionally accepted
Xuejin Wang Xuejin Wang 1Danxia Gu Danxia Gu 2Liwei Zhang Liwei Zhang 1Yuchen Wu Yuchen Wu 1*Rong Zhang Rong Zhang 1Kewei Li Kewei Li 3*Haitao Ren Haitao Ren 4*
  • 1 Department of Clinical Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
  • 2 Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Hangzhou, Jiangsu Province, China
  • 3 Key Laboratory of Laboratory Medicine, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • 4 Department of Cardiovascular Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Edwardsiella tarda is frequently isolated from aquatic animals and environments.While human infections caused by E. tarda are rare, some extraintestinal infections can be severe. This case report describes a patient with cellulitis of the right upper extremity of unknown origin. mNGS indicated that the patient was infected with E. tarda. Antimicrobial susceptibility testing revealed that the isolate was resistant to quinolones and trimethoprim/sulfamethoxazole. The isolate, positive for four virulence genes (fimA, gadB, mukF, sodB), was confirmed to be virulent using the Galleria mellonella larvae model. Following early pus drainage and a 9-day course of imipenem, the patient ultimately recovered. This case report aims to illustrate the presentation, diagnosis, and management of an uncommon cellulitis caused by drugresistant, virulent E. tarda.

    Keywords: Edwardsiella tarda, Cellulitis, Virulence, resistant, mNGS (metagenomic next-generation sequencing)

    Received: 13 Jun 2024; Accepted: 13 Sep 2024.

    Copyright: © 2024 Wang, Gu, Zhang, Wu, Zhang, Li and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuchen Wu, Department of Clinical Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Kewei Li, Key Laboratory of Laboratory Medicine, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China
    Haitao Ren, Department of Cardiovascular Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang Province, China

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