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REVIEW article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1406547
This article is part of the Research Topic Biology of Mesenchymal Stromal Cells -Emerging New Concepts to Improve Function and Scalability View all 10 articles

Therapeutic role of Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells and Their Wide Therapeutic Implications in inflammatory Bowel Disease and Other Inflammatory Disorder

Provisionally accepted
Muhammad Azhar Muhammad Azhar 1Aijun Wan Aijun Wan 2*Ying Chu Ying Chu 1*Jing Zhou Jing Zhou 1Yongmin Yan Yongmin Yan 1*Zhiliang Xu Zhiliang Xu 1*
  • 1 Changzhou Wujin People's Hospital, Changzhou, China
  • 2 Zhenjiang College, Zhenjiang, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    The chronic immune-mediated inflammatory condition known as inflammatory bowel disease (IBD) significantly affects the gastrointestinal system. While the precise etiology of IBD remains elusive, extensive research suggests that a range of pathophysiological pathways and immunopathological mechanisms may significantly contribute as potential factors.Mesenchymal stem cells (MSCs) have shown significant potential in the development of novel therapeutic approaches for various medical conditions. However, some MSCs have been found to exhibit tumorigenic characteristics, which limit their potential for medical treatments. The Extracellular Vehicles (EVs), paracrine factors play a crucial role in the therapeutic benefits conferred by MSCs. The EVs consist of proteins, microRNAs, and lipids, and are instrumental in facilitating intercellular communication. Due to the ease of maintenance, and decreased immunogenicity, tumorigenicity the EVs have become a new and exciting option for whole cell treatment. This review comprehensively assesses recent preclinical research on hUC-MSC-derived EVs as a potential IBD therapy. It comprehensively addresses key aspects of various conditions, including diabetes, cancer, dermal injuries, neurological disorders, cardiovascular issues, liver and kidney diseases, and bone-related afflictions.

    Keywords: inflammatory bowel disease, Human umbilical mesenchymal stem cells, Exosomes, Genes, extracellular vesicles

    Received: 25 Mar 2024; Accepted: 18 Jul 2024.

    Copyright: © 2024 Azhar, Wan, Chu, Zhou, Yan and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Aijun Wan, Zhenjiang College, Zhenjiang, 212028, Jiangsu Province, China
    Ying Chu, Changzhou Wujin People's Hospital, Changzhou, China
    Yongmin Yan, Changzhou Wujin People's Hospital, Changzhou, China
    Zhiliang Xu, Changzhou Wujin People's Hospital, Changzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.