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ORIGINAL RESEARCH article

Front. Med.
Sec. Hematology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1400154

Effects of integrated blood purification on haemodynamics and oxygen metabolism in children with severe sepsis

Provisionally accepted
Hekai Ma Hekai Ma Zhiyuan Wang Zhiyuan Wang Jiahao Geng Jiahao Geng Junlin Zhao Junlin Zhao Tuanjie Wang Tuanjie Wang Ling Liu Ling Liu Yuping Xu Yuping Xu Weiqing Liu Weiqing Liu Min Wang Min Wang Lan Zhao Lan Zhao Shu-Jun Li Shu-Jun Li *
  • The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the effects of integrated blood purification on haemodynamics and oxygen metabolism in children with severe sepsis. Methods: Clinical data of 12 children with severe sepsis admitted to the paediatric intensive care unit of our hospital between October 2021 and June 2022 were retrospectively analysed. All patients were treated with integrated blood purification, and changes in haemodynamic parameters, including heart rate, blood pressure, mean arterial pressure and cardiac output, and oxygen metabolism parameters (blood lactic acid, oxygen delivery, oxygen consumption and oxygen extraction rate) were observed before and after treatment. Results: The heart rate (134[106,160] vs 111[101,128], p=0.037), central venous pressure (9[7,10] vs 8[7,9], p=0.04), stroke output (28[18,43] vs 21[15,31], p=0.01), blood lactate (3.3[2,4] vs 2.5[1.3,3.6], p=0.015), oxygen consumption (165.99[121.44,230.31] vs 124.18[82.51,162.86], p=0.041) and oxygen extraction rate (38.83[31.87,44.62] vs 28.67[21.05,32.72], p=0.019) were decreased, whereas systolic blood pressure (97[83,104] vs 107[94,116], p=0.033) and central venous oxygen pressure (32[29, 37] vs 39[34,46], p=0.005) were increased in the children after treatment compared with before treatment. There were no statistically significant differences in diastolic blood pressure, mean arterial pressure, cardiac output, arterial oxygen pressure and oxygen delivery before and after treatment (all p>0.05). Conclusion: Integrated blood purification can improve haemodynamic and oxygen metabolism parameters in children with severe sepsis, with a high value in clinical application.

    Keywords: Blood purification, Severe sepsis, Haemodynamics, oxygen metabolism, Children

    Received: 13 Mar 2024; Accepted: 20 Sep 2024.

    Copyright: © 2024 Ma, Wang, Geng, Zhao, Wang, Liu, Xu, Liu, Wang, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shu-Jun Li, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.