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CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1398714
This article is part of the Research Topic Application and Reliability Assessment of Next Generation Sequencing (NGS) and targeted NGS (tNGS) in the Diagnosis of Infectious Diseases-Volume III View all 30 articles
A Case Report: Comorbidity of Rhinocerebral mucormycosis and pulmonary aspergillosis with challenging diagnosis
Provisionally accepted- Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Background: Mucormycosis is a rare opportunistic invasive fungal disease. Rhinocerebral mucormycosis (RCM) is clinically difficult to diagnose, and patients often die due to delayed diagnosis.Case description: A patient with concurrent pulmonary aspergillosis was diagnosed with RCM caused by Rhizopus through metagenomic Next-Generation Sequencing (mNGS). Despite comprehensive treatment including surgery, amphotericin B, and posaconazole, the patient tragically passed away. The treatment was delayed due to repeated cultures of secretions were negative and pathological examination could not clarify which fungus is infected.The clinical manifestations of RCM are not specific in the early stage, but the infection progresses rapidly. Therefore, early and accurate diagnosis is very important. mNGS is helpful for patients suspected of RCM, especially when conventional microbiology tests were negative.
Keywords: Rhinocerebral mucormycosis, Rhizopus, metagenomic next-generation sequencing, case report, Amphotericin B, Posaconazole
Received: 10 Mar 2024; Accepted: 09 Sep 2024.
Copyright: © 2024 Wang, Huang, Ma and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yangyiyi Huang, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Haina Ma, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Guokang Fan, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
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