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ORIGINAL RESEARCH article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1397111
This article is part of the Research Topic Diagnosis and Management of Acute, Chronic, and Autoimmune Pancreatitis View all 3 articles

A dose-response correlation between smoking and severity of acute pancreatitis: A propensity score-matched study

Provisionally accepted
Runzhuo Li Runzhuo Li 1,2,3*Wanyun Tang Wanyun Tang 2*Sun Yan Sun Yan 4*Xiaohan Yu Xiaohan Yu 2*Lian Hu Lian Hu 1*
  • 1 First People's Hospital of Yibin, Sichuan, China
  • 2 China Medical University, Shenyang, Liaoning Province, China
  • 3 Dandong Central Hospital, Dandong, China
  • 4 Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Background: Acute pancreatitis, among the most prevalent gastrointestinal disorders, exhibits a continual rise in its incidence recent years. This study endeavor to explore the correlation between smoking exposure and the severity of acute pancreatitis (AP).Methods: 508 patients diagnosed as acute pancreatitis (AP) were included in our data analysis.Patients were categorized based on their smoking pack-years into four groups: light, moderate, heavy, and non-smokers. Outcomes were classified as two: "mild acute pancreatitis (MAP)" and "moderately severe acute pancreatitis (MSAP) or severe acute pancreatitis (SAP)". We conducted propensity score matching (PSM) to adjust confounding factors and multivariable logistic regression analysis to determine adjusted odds ratios and 95% confidence intervals. Additionally, a dose-dependent association analysis between smoking exposure and the incidence rate of "MSAP or SAP" was performed.Results: Smokers exhibited a higher risk of "MSAP or SAP" compared to non-smokers, both before (17.1% vs. 54.9%, p < 0.001) and after (9.4% vs. 24.7%, p < 0.001) PSM. With an area under the ROC curve of 0.708, smoking showed a moderate level of predictive ability. Furthermore, propensity score matching analysis showed that patients who smoked compared to non-smokers had significantly higher risks of "MSAP or SAP" for light smoking (OR 3.76, 95% CI 1.40-10.07, p = 0.008), moderate smoking (OR 4.94,, p < 0.001), and heavy smoking (OR 8.08, 95% CI 3.39-19.25, p < 0.001).Smoking is an independent risk factor that can raise the severity of pancreatitis.Moreover, the severity of acute pancreatitis escalates in tandem with the accumulation of pack-years of smoking.

    Keywords: Smoking, acute pancreatitis, Propensity score-matching, severity grading, Dose-respons relationship

    Received: 06 Mar 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Li, Tang, Yan, Yu and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Runzhuo Li, First People's Hospital of Yibin, Sichuan, China
    Wanyun Tang, China Medical University, Shenyang, 110122, Liaoning Province, China
    Sun Yan, Chongqing Medical University, Chongqing, 400016, China
    Xiaohan Yu, China Medical University, Shenyang, 110122, Liaoning Province, China
    Lian Hu, First People's Hospital of Yibin, Sichuan, China

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