AUTHOR=Huong Nguyen Thi Kim , Long Bui , Doanh Le Huu , Thoai Tran Minh , Hang Nguyen Thi , Khoi Le , Nu Pham Thi 

TITLE=Associations of different inflammatory factors with atherosclerosis among patients with psoriasis vulgaris

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1396680

DOI=10.3389/fmed.2024.1396680

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Background</title><p>This study aimed to measure the associations between different inflammatory factors, namely interleukin (IL)-17A, tumor necrosis factor (TNF)-α, and high-sensitivity C-reactive protein (hs-CRP), and atherosclerosis in patients with psoriasis vulgaris.</p></sec><sec id="sec2"><title>Methods</title><p>A cross-sectional study was conducted at two hospitals in Hanoi, Vietnam. A total of 125 patients with psoriasis vulgaris and 50 healthy controls were recruited. Clinical characteristics and atherosclerosis were assessed. IL-17A, TNF-α, and hs-CRP levels were measured.</p></sec><sec id="sec3"><title>Results</title><p>Psoriasis vulgaris patients with atherosclerosis had higher levels of hs-CRP (median = 1.22; interquartile range—IQR = 0.34–12.11) and IL-17A (median = 1.30; IQR = 0.43–4.28), but a lower level of TNF-α (median = 0.54; IQR = 0.13–3.41) compared to those without atherosclerosis (<italic>p</italic> &lt; 0.05). Only LogIL-17A was positively related to atherosclerosis in psoriasis patients (Odds Ratio—OR = 2.16, 95% CI = 1.06–4.38, <italic>p</italic> &lt; 0.05). After excluding systemically treated patients, LogIL-17A and Log TNF-α were associated with the likelihood of atherosclerosis (<italic>p</italic> &lt; 0.05).</p></sec><sec id="sec4"><title>Conclusion</title><p>This study suggests a link between elevated levels of IL-17A and TNF-α and subclinical atherosclerosis. Further investigation on a larger scale is required to establish the causality of this relationship.</p></sec>