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ORIGINAL RESEARCH article

Front. Med.
Sec. Precision Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1396496

A National Framework for Transition to precision Medicine

Provisionally accepted
Sepehr Ghazinoory Sepehr Ghazinoory 1*Samaneh Karimi Samaneh Karimi 2fatemeh saghafi fatemeh saghafi 2
  • 1 Tarbiat Modares University, Tehran, Iran
  • 2 University of Tehran, Tehran, Tehran, Iran

The final, formatted version of the article will be published soon.

    Precision medicine is reshaping healthcare by offering tailored interventions that address individual variability, transforming patient care and outcomes.PM is based on providing health-oriented services according to genetic characteristics, individual and family medical history, lifestyle, place of residence and other personalized characteristics. This study aims to determine an appropriate framework for moving towards PM in Iran. First, the global transition framework to PM was drawn by a systematic review, then a framework for transition to PM in Iran was drawn by case study through semi-structured interviews, expert panel & AHP questionnaire. The statistical population of the research was PM specialists and researchers and patients whose PM plays a significant role in their diagnosis and treatment. The sampling method was non-random with a combination of purposive and snowball techniques. The results from the systematic review show for transition to PM, we must first move from common medicine to stratified medicine and then PM. Moving towards PM requires strong economic, social, political, institutional, industrial infrastructures and most importantly technological infrastructures. These infrastructures will vary from country to country. In general, coexistence between the health system and PM technologies did not exist in the beginning, but it will emerge with its development. The resistance of health system in acceptance PM will gradually decrease. Also, the government plays key role in the early phases, while the role of market & PM demand becomes more prominent during the development. New health actors will also develop PM and out-of-date actors will be deleted or replaced. But moving towards PM is slightly different in Iran, particularly in middle phases of transition.

    Keywords: precision medicine, personalized medicine, Stratified Medicine, Transition framework, Sociotechnical transition, Transition pathway

    Received: 25 May 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Ghazinoory, Karimi and saghafi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sepehr Ghazinoory, Tarbiat Modares University, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.