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ORIGINAL RESEARCH article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1393498
This article is part of the Research Topic Gastrointestinal Tract Infections: A Global Perspective View all 11 articles

Helicobacter pylori Eradication Following Endoscopic Resection Might Prevent Metachronous Gastric Cancer: A Systematic Review and Meta-analysis of researches from Japan and Korea

Provisionally accepted
Tian-hang Yu Tian-hang Yu Dan Bai Dan Bai Kai Liu Kai Liu Wei-Han Zhang Wei-Han Zhang Xin-Zu Chen Xin-Zu Chen *Jian-Kun Hu Jian-Kun Hu
  • West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    The systematic review and meta-analysis was performed to evaluate the preventive effectiveness of Helicobacter pylori eradication against metachronous gastric cancer (MGC) or dysplasia following endoscopic resection (ER) for early gastric cancer (EGC) or dysplasia. Methods: PubMed, Cochrane Library, MEDLINE and EMBASE were searched until October 31, 2023, and literatures of randomized controlled trials or cohort studies were peer-reviewed. The incidence of metachronous gastric lesions (MGLs) including MGC or dysplasia were compared between Helicobacter pylori persistent and negative groups, between eradicated and negative groups, and between eradicated and persistent groups.Results: Totally, 21 eligible studies including 82256 observations were analyzed. Compared to those never infected, Helicobacter pylori persistent group (RR=1.58, 95% CI 0.98-2.53) trended to have higher risk of MGLs and significantly in partial subgroups, while post-ER eradicated group (RR=0.79, 95% CI 0.43-1.45) didn't increase risk of MGLs. Moreover, successful post-ER eradication could significantly decrease the risk of MGLs (RR=0.54, 95% CI 0.44-0.65) comparing to those persistently infected. Sensitivity analysis obtained generally consistent results, and no significant publication bias was found.The persistent Helicobacter pylori infection trends to increase the post-ER incidence of MGC or dysplasia, but post-ER eradication can decrease the risk correspondingly. Post-ER screening and eradication of Helicobacter pylori has preventive effectiveness on MGC, and should be all-included recommended to post-ER patients.

    Keywords: Early Gastric Cancer, Metachronous gastric cancer, Helicobacter pylori, Endoscopic resection, eradication

    Received: 01 Apr 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Yu, Bai, Liu, Zhang, Chen and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xin-Zu Chen, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

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