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ORIGINAL RESEARCH article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1385294
This article is part of the Research Topic Ocular Imaging Technology and Application View all 11 articles

Swept-source optical coherence tomography in ocular surface diseases: anterior segment analysis repeatability and its limits

Provisionally accepted
Alberto Recchioni Alberto Recchioni 1,2,3Abinaya Venkataraman Abinaya Venkataraman 4Saaeha Rauz Saaeha Rauz 1,2Alberto Domínguez-Vicent Alberto Domínguez-Vicent 4*
  • 1 University of Birmingham, Birmingham, England, United Kingdom
  • 2 Birmingham and Midland Eye Centre, Birmingham, United Kingdom
  • 3 Optometry & Vision Sciences Group, School of Life & Health Sciences, Aston University, Birmingham, United Kingdom
  • 4 Karolinska Institutet (KI), Solna, Stockholm, Sweden

The final, formatted version of the article will be published soon.

    This study aims to evaluate the repeatability of anterior segment optical coherence tomography (AS-OCT) in diverse ocular surface disorder (OSD) cohorts, exploring various anterior segment parameters and their accuracy in different disease groups.A total of 239 participants across six distinct OSD groups and healthy controls underwent nonmydriatic AS-OCT imaging using the Tomey CASIA 2 device. Anterior segment parameters including anterior chamber depth, width, angle metrics, corneal thickness, keratometry, lens vault, and others were meticulously assessed. Statistical analyses determined repeatability limits and coefficients of variation for each parameter within the different OSD cohorts.Repeatability for anterior chamber and corneal parameters remained consistent across all OSD groups, indicating minimal impact of ocular surface disease on accuracy. The coefficient of variation (CoV) for the trabecular iris-space area was about 20% for all cohorts. Ocular surface inflammation emerged as a key factor in dry eye, affecting immune-mediated and non-immune conditions alongside age-related ocular surface changes. While anterior chamber depth measurements showed variations, particularly in immune (CoV=2.5%) and non-immune (CoV=3.8%) OSD groups, parameters like anterior chamber width and angle to angle showed similar values among the cohorts. Keratometry measures remained stable despite OSD (CoV lower than 1%).The Tomey CASIA 2 demonstrated reliable repeatability for measuring anterior segment parameters in diverse OSD cohorts. Despite challenges posed by dry eye conditions, this technology holds promise in assessing OSD, suggesting potential clinical protocols similar to those in healthy controls.

    Keywords: Ocular surface disorders1, Repeatability2, Anterior segment OCT3, Corneal topography4, anterior segment parameters5

    Received: 12 Feb 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Recchioni, Venkataraman, Rauz and Domínguez-Vicent. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Alberto Domínguez-Vicent, Karolinska Institutet (KI), Solna, 171 77, Stockholm, Sweden

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.