AUTHOR=Cao Weihua , Jiang Tingting , Deng Wen , Wang Shiyu , Li Xinxin , Zhang Ziyu , Zhang Lu , Lu Yao , Chang Min , Liu Ruyu , Wu Shuling , Shen Ge , Gao Yuanjiao , Hao Hongxiao , Chen Xiaoxue , Hu Leiping , Xu Mengjiao , Yi Wei , Xie Yao , Li Minghui 

TITLE=Insulin resistance has closer correlation with the occurrence of metabolic dysfunction associated steatotic liver disease diagnosed by liver biopsy

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1384927

DOI=10.3389/fmed.2024.1384927

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Objective</title><p>To explore any correlation between serum urate (SU) level or insulin resistance (IR) and metabolic dysfunction associated steatotic liver disease (MASLD) in patients with metabolic syndrome (MS).</p></sec><sec id="sec2"><title>Methods</title><p>Data from all MASLD patients, diagnosed by liver biopsy, were enrolled and divided into MASLD alone group and MASLD with MS group. They were subdivided into hyperuricemia group and normal SU group to find correlation between SU/IR and MASLD in patients with MS and independent risk factors for MASLD.</p></sec><sec id="sec3"><title>Results</title><p>Data from 539 MASLD patients were analyzed. Body mass index (BMI) (<italic>p</italic> = 0.000), waist circumference (WC) (<italic>p</italic> = 0.004), and low-density lipoprotein (LDL) (<italic>p</italic> = 0.000) were dramatically higher in MASLD with MS group than those with MASLD alone; MASLD with MS patients had significantly more family history of diabetes (<italic>p</italic> = 0.000) and hypertension (<italic>p</italic> = 0.000) than patients with MASLD alone. Height (<italic>p</italic> = 0.000), weight (<italic>p</italic> = 0.000), BMI (<italic>p</italic> = 0.000) and WC (<italic>p</italic> = 0.001), and LDL (<italic>p</italic> = 0.007) were dramatically higher in hyperuricemia patients than those with normal SU. SU was inversely associated with age (<italic>p</italic> = 0.000) and high-density lipoprotein (HDL) (<italic>p</italic> = 0.003), and positively correlated with weight (<italic>p</italic> = 0.000), BMI (<italic>p</italic> = 0.000) and WC (<italic>p</italic> = 0.000), TG (<italic>p</italic> = 0.000), and LDL (<italic>p</italic> = 0.000). Logistic Regression analysis showed that age (<italic>p</italic> = 0.031), TG (<italic>p</italic> = 0.002), LDL (<italic>p</italic> = 0.010), HbA1c (<italic>p</italic> = 0.026), and family history of hypertension (<italic>p</italic> = 0.000) may be independent risk factors for MASLD in patient with MS.</p></sec><sec id="sec4"><title>Conclusion</title><p>Insulin resistance (IR) in MASLD patients with MS, but not higher SU levels, has closer correlation with the occurrence of MASLD in patients with family history of hypertension and diabetes having higher BMI, LDL, HbA1c.</p></sec>