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ORIGINAL RESEARCH article

Front. Med.
Sec. Nephrology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1381942

Influence of a simple cyst on kidney function

Provisionally accepted
Vigen Malkhasyan Vigen Malkhasyan 1Tukhtasin Makhmudov Tukhtasin Makhmudov 1Yunus Gilfanov Yunus Gilfanov 2Igor Semenyakin Igor Semenyakin 2Sergey Sukhikh Sergey Sukhikh 1Bagrat Grigoryan Bagrat Grigoryan 1*Dmitry Pushkar Dmitry Pushkar 1
  • 1 S.P. Botkin Clinical Hospital, Moscow, Moscow Oblast, Russia
  • 2 Independent researcher, Moscow, Russia

The final, formatted version of the article will be published soon.

    In this prospective cohort study, we analyze data on 109 patients who sought counseling with a simple kidney cyst. Patients with solitary cyst of the right or left kidney, grade I-IIF according to the Bosniak classification, were included. Split glomerular filtration rate (sGFR) was calculated. The maximum size of the cyst, single kidney volumes (SKV) and the volume of the lost (atrophied) parenchyma were estimated with computed tomography (CT) scan of the urinary tract with contrast.The average difference between the sGFR of a healthy and affected kidney cyst was 11 [8.70; 13.44] ml/min, which is a statistically significant value (p=0.001). Correlation analysis revealed a statistically significant relationship between the proportion of lost parenchyma and the maximum cyst size: ρ = 0.37 with 95% CI [0.20; 0.52] (p = 0). A multivariate logistic regression model showed that a statistically significant factor influencing the likelihood of a significant decrease in sGFR is the percentage of lost kidney parenchyma (OR=1.13; p=0).The growth of kidney cyst causes atrophy of the renal parenchyma and a decrease in the sGFR of the affected kidney. An increase in the volume of the atrophied parenchyma leads to a decrease in the sGFR of the affected kidney.

    Keywords: simple kidney cyst, renal cyst, Kidney function, Total kidney volume, single kidney volume, Split glomerular filtration rate, renal parenchyma loss

    Received: 04 Feb 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Malkhasyan, Makhmudov, Gilfanov, Semenyakin, Sukhikh, Grigoryan and Pushkar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bagrat Grigoryan, S.P. Botkin Clinical Hospital, Moscow, 125284, Moscow Oblast, Russia

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