AUTHOR=Liu Wen-long , Wu Lan-ting , Wang Jia-lin , Sun Jiao , Cheng Xue-ru , Zhou Zhuo-hua , Guan Jia-xin , Wang Yan-ling , Meng Zhao-yang 

TITLE=Effect of PCI on ophthalmic artery hemodynamics in patients with acute coronary syndrome

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1367900

DOI=10.3389/fmed.2024.1367900

ISSN=2296-858X

ABSTRACT=<sec><title>Purpose</title><p>We aimed to explore the effects of percutaneous coronary intervention (PCI) on the ophthalmic artery (OA) hemodynamics in patients with acute coronary syndrome (ACS).</p></sec><sec><title>Methods</title><p>A total of 73 participants (Group0: healthy controls, Group1: Patients with ACS underwent PCI &lt; 3 months, Group2: Patients with ACS underwent PCI ≥ 3 months) were enrolled. Computed tomographic angiography images were used to construct three-dimensional models of participants' OAs. Numerical simulations based on computational fluid dynamics were used to acquire hemodynamic parameters.</p></sec><sec><title>Results</title><p>The angle between the OA and internal carotid artery in Group2 was significantly larger compared with Group0 and Group1 (<italic>P</italic> = 0.003 and <italic>P</italic> = 0.044). Hemodynamic simulation showed a significantly slower OA blood velocity in Group1 than in the control (<italic>P</italic> &lt; 0.001) and Group2 (<italic>P</italic> = 0.033). Lower wall shear stress was found in Group1 than that in control (<italic>P</italic> = 0.040). Patients after PCI had a higher wall pressure than healthy controls (<italic>P</italic> = 0.012 and <italic>P</italic> = 0.004). Mass flow ratios were decreased in Group1 and Group2 (<italic>P</italic> = 0.021 and <italic>P</italic> = 0.002). The hemodynamic parameters of OA were correlated with several clinical indicators.</p></sec><sec><title>Conclusions</title><p>The OA blood flow velocity of patients with ACS after PCI initially slowed down, which increased the risk of plaque formation, and then showed an increasing trend. There was a correlation between OA hemodynamic parameters and clinical indexes related to cardiac stress. Ischemia-reperfusion injury and changes in blood flow status after PCI may affect OA morphology and hemodynamics, leading to ocular lesions.</p></sec><sec><title>Trial registration</title><p>ChiCTR2100050428.</p></sec>