AUTHOR=Long Xiaolu , An Ning , Li Chunhui , Zhu Hui , Li Haojie , Yu Qiuxia , Que Yimei , Xu Menglei , Li Zhe , Chen Wei , Wang Shuai , Wang Di , Li Chunrui 

TITLE=Case report: Light-chain amyloidosis responsive to selinexor in combination with daratumumab and dexamethasone (SDd) therapy

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1363805

DOI=10.3389/fmed.2024.1363805

ISSN=2296-858X

ABSTRACT=<p>The outcome of AL amyloidosis remains poor, particularly in patients with advanced organ involvement which takes long time to recovery. We conducted an observational study of two patients with AL amyloidosis treated with SDd regimen. Both patients successfully achieved significant hematological and organ responses without severe adverse events, and the time to organ response was remarkably shorter than previously reported. Notably, an over 15% reduction in interventricular septal thickness (IVST) was observed in patient#2 within 6 months. Up to now, SDd therapy has not been previously reported in AL amyloidosis and may be a promising option for these patients.</p>