AUTHOR=Niedźwiedź Michał , Narbutt Joanna , Siekierko Aleksandra , Skibińska Małgorzata , Kwiek Bartłomiej , Sobolewska-Sztychny Dorota , Ciążyńska Magdalena , Poznańska-Kurowska Katarzyna , Gostyński Antoni , Lesiak Aleksandra 

TITLE=Case report: Successful treatment with biologics in a pediatric patient with a severe inflammatory skin disease and novel CARD14 mutation

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1360248

DOI=10.3389/fmed.2024.1360248

ISSN=2296-858X

ABSTRACT=<p><italic>CARD14</italic> (caspase activation and recruitment domain) mutations have been associated with psoriasis vulgaris, psoriatic arthritis, generalized and palmoplantar pustular psoriasis, pityriasis rubra pilaris, and atopic dermatitis. We present a pediatric patient with a novel <italic>CARD14</italic>: c.394A &gt; T/− (Ile123Phe) mutation, diagnosed with <italic>CARD14</italic>-associated papulosquamous eruption (CAPE), who was successfully treated with biological treatment.</p>