AUTHOR=Yang Xiaobo , Ouyang Yaqi , Xu Jiqian , Shang You 

TITLE=Protocol for a systematic review and individual participant data meta-analysis of optimizing oxygen therapy in critically ill patients

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1356557

DOI=10.3389/fmed.2024.1356557

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Background</title><p>Oxygen therapy is a cornerstone treatment of critically ill patients in the intensive care unit (ICU). Whether lower oxygenation therapy brings superior survival outcomes to higher oxygenation therapy is unknown.</p></sec><sec id="sec2"><title>Methods</title><p>We will search electronic databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), International Clinical Trials Registry Platform (ICTRP), and <ext-link xlink:href="https://ClinicalTrials.gov" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">ClinicalTrials.gov</ext-link> from inception to 1 January 2024. Two authors will independently screen for all eligible clinical studies. Emails will be sent for individual participant data. The statistical analyses will be conducted using STATA 15.0 software.</p></sec><sec id="sec3"><title>Results</title><p>We will evaluate the efficacy of lower oxygenation therapy compared with higher oxygenation therapy based on individual participant data.</p></sec><sec id="sec4"><title>Conclusion</title><p>This study will offer clinical evidence for oxygen therapy in ICU patients.</p></sec>