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STUDY PROTOCOL article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1356557

Protocol for a systematic review and individual participant data meta-analysis of optimizing oxygen therapy in critically ill patients

Provisionally accepted
Xiaobo Yang Xiaobo Yang *Yaqi Ouyang Yaqi Ouyang Jiqian Xu Jiqian Xu You Shang You Shang
  • Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

The final, formatted version of the article will be published soon.

    Background: Oxygen therapy is a cornerstone treatment of critically ill patients in the intensive care unit (ICU). Whether lower oxygenation therapy brings superior survival outcomes to higher oxygenation therapy is unknown.Methods: We will search electronic databases: Pubmed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CEN-TRAL), International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov from inception to January 1st, 2024. Two authors will independently screen for all eligible clinical studies. Emails will be sent for individual participant data. The statistical analyses will be conducted by STATA 15.0 software.We will evaluate the efficacy of lower oxygenation therapy compared with higher oxygenation therapy based on individual participant data.This study will offer clinical evidence for oxygen therapy in ICU patients.

    Keywords: Oxygen therapy, Intensive Care Unit, Meta-analysis, Individual participant data, Systematic review, protocol

    Received: 23 Jan 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Yang, Ouyang, Xu and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaobo Yang, Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.