AUTHOR=Fererberger Tanja , Buechler Christa , Kandulski Arne , Elger Tanja , Loibl Johanna , Schmid Stephan , Sommersberger Stefanie , Gunawan Stefan , Zundler Sebastian , Huss Muriel , Bettenworth Dominik , Kempa Sally , Weidlich Simon , Föh Bandik , Huang Xinyu , Grzegorzek Marcin , Derer-Petersen Stefanie , Günther Ulrich L. , Marquardt Jens U. , Kunst Claudia , Gülow Karsten , Müller Martina , Sina Christian , Schmelter Franziska , Tews Hauke C. 

TITLE=Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1334865

DOI=10.3389/fmed.2024.1334865

ISSN=2296-858X

ABSTRACT=<sec><title>Intoduction</title><p>Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification.</p></sec><sec><title>Methods</title><p>Nuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC.</p></sec><sec><title>Results</title><p>In particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM.</p></sec><sec><title>Discussion</title><p>These results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM.</p></sec>