AUTHOR=Wang Chengyuan , Yao Meixiang , Zhong Hongguang , Meena Stephene S. , Shu Fuxing , Nie Shaoping , Xie Mingyong 

TITLE=Natural foods resources and dietary ingredients for the amelioration of Helicobacter pylori infection

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1324473

DOI=10.3389/fmed.2023.1324473

ISSN=2296-858X

ABSTRACT=<p><italic>Helicobacter pylori (H. pylori)</italic> is a gastric-persistent pathogen that can cause peptic ulcer disease, gastric cancer, and mucosal-associated lymphoid tissue lymphoma. This pathogen is commonly treated with antibiotic-based triple or quadruple therapy. However, antibiotic therapy could result in the bacterial resistance, imbalance of gut microbiota, and damage to the liver and kidneys, etc. Therefore, there is an urgent need for alternative therapeutic strategies. Interestingly, natural food resources, like vegetables, fruits, spices, and edible herbs, have potent inhibitory effects on <italic>H. pylori</italic>. In this review, we systematically summarized these foods with supporting evidence from both animal and clinical studies. The results have indicated that natural foods may possess temporary inhibition effect on <italic>H. pylori</italic> rather than durable eradication, and may help to reduce <italic>H. pylori</italic> colonization, enhance the effect of antibiotics and modulate the host’s immune response.</p>