AUTHOR=Meng Chunli , Liu Kai 

TITLE=Higher levels of systemic immune-inflammatory index are associated with the prevalence of gallstones in people under 50 years of age in the United States: a cross-sectional analysis based on NHANES

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1320735

DOI=10.3389/fmed.2023.1320735

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Introduction</title><p>Inflammation plays a significant role in gallstones formation. The prognosis of various illnesses was initially predicted using the systemic immune-inflammatory index (SII). We performed an updated analysis on the impact of SII and gallstones.</p></sec><sec id="sec2"><title>Methods</title><p>To investigate the connection between the SII and gallstones occurrence in a sample of individuals from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020, we employed logistic regression analysis, subgroup analysis, and smoothing curve fitting.</p></sec><sec id="sec3"><title>Results</title><p>In our study, an aggregate of 4,950 individuals over the age of 20 were enrolled, and 429 of them claimed to have gallstones. A fully adjusted model showed that the third and fourth quartiles of SII was parallel associated with gallstones in adults (OR = 2.43, 95% CI = 1.39–4.26; OR = 2.97, 95% CI = 1.72–5.16) under 50 years. Subgroup analysis and smoothed curve fitting provided evidence in favor of this finding.</p></sec><sec id="sec4"><title>Conclusion</title><p>According to our research, gallstones are more likely to occur in US adults younger than 50 years.</p></sec>