AUTHOR=Zhu Nan , Song Yongfeng , Zhang Chen , Wang Kai , Han Junming 

TITLE=Association between the peripheral neutrophil-to-lymphocyte ratio and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1294425

DOI=10.3389/fmed.2023.1294425

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Background</title><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes frequently co-occur, imposing a tremendous medical burden. A convenient and effective MASLD indicator will be beneficial to the early diagnosis of disease. In the clinical laboratory, the neutrophil-to-lymphocyte ratio (NLR) is a readily accessible hematological marker. This study designed to determine the relation between the NLR and MASLD in type 2 diabetes patients.</p></sec><sec id="sec2"><title>Methods</title><p>Data from 1,151 type 2 diabetes inpatients without infections, malignancy or hematological diseases who were recruited from 2016 through 2022 were analyzed in the retrospective study. The patients were stratified into NLR tertiles (total population: high NLR level &gt; 2.18; middle NLR level: 1.58–2.18; low NLR level &lt; 1.58), with additional subgroup stratification by sex (men: high NLR level &gt; 2.21; middle NLR level: 1.60–2.21; and low NLR level &lt; 1.60; women: high NLR level &gt; 2.12; middle NLR level: 1.53–2.12; and low NLR level &lt; 1.53). After adjusting for confounders (age, sex, weight, Glu, ALT and TG) associated with MASLD, the odds ratio (OR) and the corresponding 95% confidence interval (CI) of the NLR were obtained by using a binary logistic regression analysis to verify the correlation between the NLR and MASLD.</p></sec><sec id="sec3"><title>Results</title><p>Compared to non-MASLD patients, MASLD patients had higher weight, blood glucose, insulin and C-peptide, worse liver function (higher ALT and GGT), lower HDL (all <italic>p</italic> &lt; 0.05), and lower NLR (<italic>p</italic> &lt; 0.001). The prevalence of MASLD was 43.75% (high NLR level), 55.21% (middle NLR level) and 52.22% (low NLR level) (<italic>p</italic> &lt; 0.05). Compared to those of the high NLR level, the adjusted ORs and 95% CIs of the middle and low NLR levels were 1.624 (95% CI: 1.141–2.311) and 1.456 (95% CI: 1.025–2.068), for all subjects, while they were 1.640 (95% CI: 1.000–2.689) and 1.685 (95% CI: 1.026–2.766), for men.</p></sec><sec id="sec4"><title>Conclusion</title><p>A low NLR is associated with a greater risk of MASLD.</p></sec>