AUTHOR=Zhang Yingyi , Yu Xinfeng , Zhou Chengcong , Fu Keqi , Luo Huan , Wu Chengliang TITLE=Targeting cellular senescence in senile osteoporosis: therapeutic potential of traditional Chinese medicine JOURNAL=Frontiers in Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1288993 DOI=10.3389/fmed.2023.1288993 ISSN=2296-858X ABSTRACT=
Senile osteoporosis (SOP) is a prevalent manifestation of age-related bone disorders, resulting from the dysregulation between osteoblast (OB)-mediated bone formation and osteoclast (OC)-mediated bone resorption, coupled with the escalating burden of cellular senescence. Traditional Chinese medicine (TCM) herbs, renowned for their remarkable attributes encompassing excellent tolerability, low toxicity, heightened efficacy, and minimal adverse reactions, have gained considerable traction in OP treatment. Emerging evidence substantiates the therapeutic benefits of various TCM formulations and their active constituents, including Zuogui wan,