AUTHOR=Wang Lu , Dai Wen , Zhu Ruiyao , Long Tingting , Zhang Zhaocai , Song Zhenju , Mu Sucheng , Wang Shasha , Wang Huijuan , Lei Jiaxi , Zhang Jing , Xia Wenfang , Li Guang , Gao Wenwei , Zou Handong , Li Yan , Zhan Liying TITLE=Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy JOURNAL=Frontiers in Medicine VOLUME=10 YEAR=2024 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1278879 DOI=10.3389/fmed.2023.1278879 ISSN=2296-858X ABSTRACT=
Sepsis-induced cardiomyopathy (SIC) is characterized by high mortality and poor outcomes. This study aimed to explore the relationship between testosterone and soluble ST2 (sST2) and all-cause mortality in patients with SIC. Clinical data from SIC patients at Renmin Hospital of Wuhan University from January 2021 and March 2023 were reviewed. Serum testosterone and sST2 were measured at admission. Kaplan–Meier analysis and receiver operative characteristic curve (ROC) were used to estimate the predictive values of testosterone and sST2 on 28 days and 90 days mortality of SIC. A total of 327 male subjects with SIC were enrolled in this study. During the 28 days and 90 days follow-up, 87 (26.6%) and 103 deaths (31.5%) occurred, respectively. Kaplan–Meier analysis showed significantly higher 28 days and 90 days survival in patients with higher testosterone and decreased sST2 levels (