AUTHOR=Wang Jun , Ma Liping 

TITLE=Tuberculosis patients with special clinical conditions treated with contezolid: three case reports and a literature review

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1265923

DOI=10.3389/fmed.2023.1265923

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Background</title><p>Contezolid is a novel oxazolidinone antibacterial agent, but there have been no reports of any pertinent clinical studies for the treatment of tuberculosis (TB). This was the first report of three TB patients who were successfully treated with contezolid.</p></sec><sec id="sec2"><title>Case presentation</title><p>Case 1 was TB complicated by myelosuppression syndrome. Case 2 was drug-resistant TB complicated by cirrhosis and anemia. Case 3 was drug-resistant TB complicated by liver transplantation that developed severe anemia after linezolid treatment. Following contezolid therapy, the three patients’ symptoms improved significantly, and no adverse reactions were observed. The chest computed tomography (CT) examination also indicated that the therapeutic effect of this anti-TB regimen was as expected.</p></sec><sec id="sec3"><title>Conclusion</title><p>Contezolid showed good efficacy and fewer side effects in the treatment of TB. It may be a promising TB treatment.</p></sec>