AUTHOR=Krausser Lena , Chauvaux Elien , Van Dyck-Lippens Magalie , Yssouf Amina , Assoumani Younoussa , Tortosa Pablo , de Jong Bouke Catherine , Braet Sofie Marijke 

TITLE=Ticks are unlikely to play a role in leprosy transmission in the Comoros (East Africa) as they do not harbour M. leprae DNA

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1238914

DOI=10.3389/fmed.2023.1238914

ISSN=2296-858X

ABSTRACT=<sec><title>Introduction</title><p>Leprosy, one of the oldest known human diseases, continues to pose a global challenge for disease control due to an incomplete understanding of its transmission pathways. Ticks have been proposed as a potential contributor in leprosy transmission due to their importance as vectors for other infectious diseases.</p></sec><sec><title>Methods</title><p>In 2010, a sampling of ticks residing on cattle was conducted on the islands Grande Comore, Anjouan, and Mohéli which constitute the Union of the Comoros where leprosy remains endemic. To investigate the potential role of ticks as a vector in transmission of leprosy disease, molecular analyses were conducted.</p></sec><sec><title>Results</title><p>Out of the 526 ticks analysed, none were found to harbour <italic>Mycobacterium leprae</italic> DNA, as determined by a quantitative polymerase chain reaction (qPCR) assay targeting a family of dispersed repeats (RLEP) specific to <italic>M. leprae</italic>.</p></sec><sec><title>Discussion</title><p>Therefore, our results suggest that in the Union of the Comoros, ticks are an unlikely vector for <italic>M. leprae</italic>.</p></sec>