AUTHOR=Michelerio Andrea , Tomasini Carlo , Fiandrino Giacomo , De Amici Mara , Varettoni Marzia , Defrancesco Irene , Cavalloni Chiara , Brazzelli Valeria , Derlino Federica , Paulli Marco , Arcaini Luca , Vassallo Camilla TITLE=Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study JOURNAL=Frontiers in Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1231003 DOI=10.3389/fmed.2023.1231003 ISSN=2296-858X ABSTRACT=Background

The pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear.

Objective

To describe the clinical, pathological and immunological findings in a series of oncohematological patients with EDHM.

Methods

An observational prospective cohort study of oncohematological patients receiving a diagnosis of EDHM between April 2017 and December 2018.

Results

A total of 15 patients with EDHM (10 females and 5 males) were identified among 422 oncohematological patients. Disease presentation varied from firm erythematous papules to more polymorphic presentations. The lesions were most prevalent on the exposed sites, 8/15 patients recalled an insect bite. Lesion seasonality was reported in 13/15 patients. IgE levels were elevated in six patients, circulating IL-4 and IL-5 were within a normal range. Twelve out of 15 patients developed skin manifestations after chemotherapy. The infiltrate could be eosinophil-rich or lymphocytic-rich. Interestingly, the histopathologic findings were in accordance with arthropod bites.

Conclusion

A role for insect bites in EDHM is supported by our findings. EDHM may be related to aggressive hematologic disease.