AUTHOR=Merad Yanis , Conrad Anne , Brosset Sophie , Schmidt Axel , Hanriat Camille , Lustig Sebastien , Laurent Frederic , Kolenda Camille , Roussel-Gaillard Tiphaine , Batailler Cecile , Ferry Tristan ,  Lyon BJI Study group 

TITLE=Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1224922

DOI=10.3389/fmed.2023.1224922

ISSN=2296-858X

ABSTRACT=<p>Among carbapenem-resistant <italic>Enterobacterales</italic>, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no clinical data support the use of this association for the treatment of bone and joint infections. We report two cases of complex bone and joint infections involving metallo-beta-lactamase-producing <italic>Enterobacterales</italic>, successfully treated at our referral center with aztreonam and ceftazidime-avibactam for 12 weeks in continuous infusions through elastomeric infusors.</p>