AUTHOR=Ebert Thomas , Behre Gerhard , Weidhase Lorenz , Vucinic Vladan , Gewert Cornelia , Semple Robert K. , Stumvoll Michael , Tönjes Anke 

TITLE=Case report: Allogeneic stem cell transplantation for type B insulin resistance

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1200037

DOI=10.3389/fmed.2023.1200037

ISSN=2296-858X

ABSTRACT=<p>Type B insulin resistance (TBIR) is a rare, often fulminant form of insulin resistance caused by autoantibodies against the insulin receptor. If left untreated, its mortality is high. Various immunosuppressive regimens have shown efficacy, but treatment effects are variable and time-delayed, and drug-induced complications may arise. We report a patient with TBIR arising as a complication of Wiskott–Aldrich syndrome. Stable remission of TBIR was achieved through allogeneic peripheral blood stem cell transplantation (PBSCT) over a follow-up period of more than 1.5 years. We thus demonstrate that PBSCT can be considered a treatment option in TBIR where conventional immunosuppressive therapy is ineffective or contraindicated.</p>