AUTHOR=Liu Xingzhu , Chen Yanfei , Yang Yanfei , Su Zhongjian , Wang Feng , Zhanghuang Chenghao , Wu Yuqin , Zhang Xing 

TITLE=Association between FGA gene polymorphisms and coronary artery lesion in Kawasaki disease

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1193303

DOI=10.3389/fmed.2023.1193303

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Objective</title><p>To investigate the correlation between <italic>FGA</italic> gene polymorphisms and coronary artery lesion in Kawasaki disease.</p></sec><sec id="sec2"><title>Methods</title><p>Two hundred and thirty four children with Kawasaki disease (KD group), 200 healthy children (normal group) and 208 children with non-KD fever (fever group) were enrolled. General clinical indicators, the concentration of serum MMPs, TIMP-1, FG-α,fibrinogen level, molecular function (FMPV/ODmax) and <italic>FGA</italic> Thr312Ala polymorphism were detected individually by testing peripheral venous blood after fasting in the morning.</p></sec><sec id="sec3"><title>Results</title><p>There was no significant difference in average age among the three groups, which were 3.03 ± 1.22 years, 3.17 ± 1.30 years, and 3.21 ± 1.31 years, respectively. Compared with those in the fever group, the levels of white blood cell count (WBC), platelet count (PLT), procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and fibrinogen (Fg) levels were significantly increased in the KD group. Red blood cell count (RBC) and hemoglobin (Hb) levels were significantly decreased (<italic>p</italic> &lt; 0.05).The concentration of serum MMPs, TIMP-1, and FG-α in the KD and fever groups were significantly higher than those in the normal group (<italic>p</italic> &lt; 0.05). The concentration of MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1, and FG-α in the KD group were significantly higher than those in the fever group (<italic>p</italic> &lt; 0.05).The KD group was divided into two subgroups,55 patients with combined CAL and 179 patients without combined CAL. The plasma fibrinogen concentration in the combined CAL group was significantly higher than that in the non-combined CAL and normal groups (<italic>p</italic> &lt; 0.01). There was no statistically significant difference in FMPV/ODmax among the three groups (<italic>p</italic> &gt; 0.05). Compared with normal group, the FGA GG, GA, and AA genotype and G, A allele frequency of the FGA gene polymorphism in the KD group showed no significant difference (<italic>p</italic> &gt; 0.05). In the KD group, the most common type in children with CAL was GA, while the most common type in children without CAL was GG.</p></sec><sec id="sec4"><title>Conclusion</title><p>MMPs and FG-α were significantly upregulated in KD patients. The proportion of <italic>FGA</italic> genotype GA in children with CAL was significantly higher than that in children without CAL, suggesting that <italic>FGA</italic> gene polymorphisms affect coronary artery lesion in children with KD.</p></sec>