AUTHOR=Konietzke Philip , Brunner Christian , Konietzke Marilisa , Wagner Willi Linus , Weinheimer Oliver , Heußel Claus Peter , Herth Felix J. F. , Trudzinski Franziska , Kauczor Hans-Ulrich , Wielpütz Mark Oliver 

TITLE=GOLD stage-specific phenotyping of emphysema and airway disease using quantitative computed tomography

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1184784

DOI=10.3389/fmed.2023.1184784

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Background</title><p>In chronic obstructive pulmonary disease (COPD) abnormal lung function is related to emphysema and airway obstruction, but their relative contribution in each GOLD-stage is not fully understood. In this study, we used quantitative computed tomography (QCT) parameters for phenotyping of emphysema and airway abnormalities, and to investigate the relative contribution of QCT emphysema and airway parameters to airflow limitation specifically in each GOLD stage.</p></sec><sec id="sec2"><title>Methods</title><p>Non-contrast computed tomography (CT) of 492 patients with COPD former GOLD 0 COPD and COPD stages GOLD 1–4 were evaluated using fully automated software for quantitative CT. Total lung volume (TLV), emphysema index (EI), mean lung density (MLD), and airway wall thickness (WT), total diameter (TD), lumen area (LA), and wall percentage (WP) were calculated for the entire lung, as well as for all lung lobes separately. Results from the 3rd-8th airway generation were aggregated (WT<sub>3-8</sub>, TD<sub>3-8</sub>, LA<sub>3-8</sub>, WP<sub>3-8</sub>). All subjects underwent whole-body plethysmography (FEV1%pred, VC, RV, TLC).</p></sec><sec id="sec3"><title>Results</title><p>EI was higher with increasing GOLD stages with 1.0 ± 1.8% in GOLD 0, 4.5 ± 9.9% in GOLD 1, 19.4 ± 15.8% in GOLD 2, 32.7 ± 13.4% in GOLD 3 and 41.4 ± 10.0% in GOLD 4 subjects (<italic>p</italic> &lt; 0.001). WP<sub>3-8</sub> showed no essential differences between GOLD 0 and GOLD 1, tended to be higher in GOLD 2 with 52.4 ± 7.2%, and was lower in GOLD 4 with 50.6 ± 5.9% (<italic>p</italic> = 0.010 – <italic>p</italic> = 0.960). In the upper lobes WP<sub>3–8</sub> showed no significant differences between the GOLD stages (<italic>p</italic> = 0.824), while in the lower lobes the lowest WP<sub>3-8</sub> was found in GOLD 0/1 with 49.9 ± 6.5%, while higher values were detected in GOLD 2 with 51.9 ± 6.4% and in GOLD 3/4 with 51.0 ± 6.0% (<italic>p</italic> &lt; 0.05). In a multilinear regression analysis, the dependent variable FEV1%pred can be predicted by a combination of both the independent variables EI (<italic>p</italic> &lt; 0.001) and WP<sub>3–8</sub> (<italic>p</italic> &lt; 0.001).</p></sec><sec id="sec4"><title>Conclusion</title><p>QCT parameters showed a significant increase of emphysema from GOLD 0–4 COPD. Airway changes showed a different spatial pattern with higher values of relative wall thickness in the lower lobes until GOLD 2 and subsequent lower values in GOLD3/4, whereas there were no significant differences in the upper lobes. Both, EI and WP<sub>5-8</sub> are independently correlated with lung function decline.</p></sec>