AUTHOR=Yang Jing , Zhang Xiaodi , Zhong Mei , Bai Yanhui , Liu Wentao , Hu Jinge , Wang Weiqun 

TITLE=Effects of brimonidine tartrate 0.2 and 0.15% ophthalmic solution on the static and dynamic pupil characteristics

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1160414

DOI=10.3389/fmed.2023.1160414

ISSN=2296-858X

ABSTRACT=<sec><title>Aims</title><p>To investigate the differences between 0.2 and 0.15% brimonidine tartrate eye drops for anti-mydriatic effects and the optical quality under different light conditions.</p></sec><sec><title>Methods</title><p>This prospective study involved 80 consecutive high myopia patients undergoing implantation of a V4c ICL. The patients were randomly instilled with brimonidine 0.2 and 0.15% 2 weeks postoperatively. Visual quality, pupil center, pupil size, and refraction under different light conditions were measured before and 0.5 h after brimonidine administration. A symptom questionnaire was also evaluated.</p></sec><sec><title>Results</title><p>There was no statistical difference in the static and dynamic pupil diameters and velocity after LS between the two groups (<italic>p</italic> &gt; 0.05). The 0.2% group had significant changes in pupil center before and after treatment, while there was no obvious movement of the 0.15% group under all illumination condition (<italic>p</italic> &gt; 0.05). The OSI after treatment of the 0.15% group was lower than that of 0.2% group (<italic>p</italic> = 0.012). The PVA9% and PVA100% of the 0.15% group was higher than that of 0.2% group in the dark (<italic>p</italic> = 0.009, <italic>p</italic> = 0.012). The HOA RMS of the 0.15% group was lower than that of 0.2% group (<italic>p</italic> = 0.016). The QIRC score in the 0.15% group was significantly higher than that in the 0.2% group (<italic>p</italic> = 0.043).</p></sec><sec><title>Conclusion</title><p>0.15 and 0.2% brimonidine tartrate eye drops had similar anti-mydriatic ability, while 0.15% group had better visual quality than 0.2% concentration, and hardly introduced pupil shift. 0.15% brimonidine tartrate eye drops may be more suitable for patients with nocturnal glare symptoms in the early postoperative period after ICL implantation.</p></sec>