AUTHOR=La Rocca Gaetano , Ferro Francesco , Baldini Chiara , Libra Alessandro , Sambataro Domenico , Colaci Michele , Malatino Lorenzo , Palmucci Stefano , Vancheri Carlo , Sambataro Gianluca 

TITLE=Targeting intracellular pathways in idiopathic inflammatory myopathies: A narrative review

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1158768

DOI=10.3389/fmed.2023.1158768

ISSN=2296-858X

ABSTRACT=<p>In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these molecules transduce their signal through a receptor coupled with Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT). In this review, we discuss the role of the JAK/STAT pathway in IIM, evaluate a possible therapeutic role for JAK inhibitors in this group of diseases, focusing on those with the strongest IFN signature (dermatomyositis and antisynthetase syndrome).</p>