AUTHOR=Verdelli Alice , Corrà Alberto , Mariotti Elena Biancamaria , Aimo Cristina , Quintarelli Lavinia , Ruffo di Calabria Valentina , Donati Marta Elettra , Bonciolini Veronica , Antiga Emiliano , Caproni Marzia TITLE=Skin gluten-related disorders: new and old cutaneous manifestations to be considered JOURNAL=Frontiers in Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1155288 DOI=10.3389/fmed.2023.1155288 ISSN=2296-858X ABSTRACT=

The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a “cutaneous-gluten sensitivity,” as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.