AUTHOR=Antropoli Alessio , Arrigo Alessandro , La Franca Lamberto , Bianco Lorenzo , Barlocci Eugenio , Fusi Emanuele , Bandello Francesco , Battaglia Parodi Maurizio TITLE=Peripheral and central capillary non-perfusion in diabetic retinopathy: An updated overview JOURNAL=Frontiers in Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1125062 DOI=10.3389/fmed.2023.1125062 ISSN=2296-858X ABSTRACT=

Capillary non-perfusion (CNP) is one of the key hallmarks of diabetic retinopathy (DR), which may develop both in the periphery and at the posterior pole. Our perspectives on CNP have extended with the introduction of optical coherence tomography angiography (OCTA) and ultra-widefield imaging, and the clinical consequences of peripheral and macular CNP have been well characterized. Fluorescein angiography (FA) continues to be the gold standard for detecting and measuring CNP, particularly when ultra-widefield imaging is available. OCTA, on the other hand, is a quicker, non-invasive approach that allows for a three-dimensional examination of CNP and may soon be regarded as an useful alternative to FA. In this review, we provide an updated scenario regarding the characteristics, clinical impact, and management of central and peripheral CNP in DR.