AUTHOR=Griffett Kristine , Burris Thomas P. TITLE=Development of LXR inverse agonists to treat MAFLD, NASH, and other metabolic diseases JOURNAL=Frontiers in Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1102469 DOI=10.3389/fmed.2023.1102469 ISSN=2296-858X ABSTRACT=
Activation of LXR activity by synthetic agonists has been the focus of many drug discovery efforts with a focus on treatment of dyslipidemia and atherosclerosis. Many agonists have been developed, but all have been hindered due to their ability to efficaciously stimulate