AUTHOR=Fistrek Prlic Margareta , Jelakovic Mislav , Brinar Marko , Grgic Dora , Romic Ivan , Marusic Zlatko , Ivandic Ema , Jelakovic Bojan , Vukovic Brinar Ivana , Krznaric Zeljko 

TITLE=Case report: Sevelamer-associated colitis—a cause of pseudotumor formation with colon perforation and life-threatening bleeding

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1097469

DOI=10.3389/fmed.2023.1097469

ISSN=2296-858X

ABSTRACT=<p>Chronic kidney disease (CKD) is a very common chronic non-communicable disease. Phosphate and calcium metabolism disorders are one of the most common features of CKD. Sevelamer carbonate is the most widely used non-calcium phosphate binder. Gastrointestinal (GI) injury associated with sevelamer use is a documented adverse effect but is underrecognized as a cause of gastrointestinal symptoms in patients with CKD. We report a case of a 74-year-old woman taking low-dose sevelamer with serious gastrointestinal adverse effects causing colon rupture and severe gastrointestinal bleeding.</p>