AUTHOR=Mollapour Sisakht Mahsa , Amirkhani Mohammad Amir , Nilforoushzadeh Mohammad Ali 

TITLE=SWI/SNF complex, promising target in melanoma therapy: Snapshot view

JOURNAL=Frontiers in Medicine

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1096615

DOI=10.3389/fmed.2023.1096615

ISSN=2296-858X

ABSTRACT=<p>Therapeutic strategies based on epigenetic regulators are rapidly increasing in light of recent advances in discovering the role of epigenetic factors in response and sensitivity to therapy. Although loss-of-function mutations in genes encoding the SWItch/Sucrose NonFermentable (SWI/SNF) subunits play an important role in the occurrence of ~34% of melanomas, the potential of using inhibitors and synthetic lethality interactions between key subunits of the complex that play an important role in melanoma progression must be considered. Here, we discuss the importance of the clinical application of SWI/SNF subunits as a promising potential therapeutic in melanoma.</p>