AUTHOR=Andagalu Ben , Lu Pinyi , Onyango Irene , Bergmann-Leitner Elke , Wasuna Ruth , Odhiambo Geoffrey , Chebon-Bore Lorna J. , Ingasia Luicer A. , Juma Dennis W. , Opot Benjamin , Cheruiyot Agnes , Yeda Redemptah , Okudo Charles , Okoth Raphael , Chemwor Gladys , Campo Joseph , Wallqvist Anders , Akala Hoseah M. , Ochiel Daniel , Ogutu Bernhards , Chaudhury Sidhartha , Kamau Edwin TITLE=Age-dependent antibody profiles to plasmodium antigens are differentially associated with two artemisinin combination therapy outcomes in high transmission setting JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.991807 DOI=10.3389/fmed.2022.991807 ISSN=2296-858X ABSTRACT=
The impact of pre-existing immunity on the efficacy of artemisinin combination therapy is largely unknown. We performed in-depth profiling of serological responses in a therapeutic efficacy study [comparing artesunate-mefloquine (ASMQ) and artemether-lumefantrine (AL)] using a proteomic microarray. Responses to over 200