AUTHOR=Shi Yue , Bi Dandan , Wang Yanhong , Li Ruofan , Wu Lijun , Zhao Cheng , Wu Zhenbiao , Duan Xinwang , Xu Jian , Zhan Feng , Yang Min , Liu Shengyun , Li Qin , Zhang Shuo , Liu Lingshan , Zhao Jiuliang , Tian Xinping , Li Xinying , Wang Qian , Zeng Xiaofeng ,  CSTAR Co-authors 

TITLE=Chinese SLE Treatment and Research Group Registry (CSTAR) XIV: the subjective well-being of patients with systemic lupus erythematosus

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.984183

DOI=10.3389/fmed.2022.984183

ISSN=2296-858X

ABSTRACT=<sec><title>Background</title><p>Systemic lupus erythematosus (SLE) can significantly influence patients’ quality of life and subjective well-being (SWB), but the relationships between clinical characteristics, SWB, and related psychological factors have been little studied.</p></sec><sec><title>Objective</title><p>To measure SWB in patients with SLE and examine how major clinical determinants, emotional variables, and related positive factors affect SWB.</p></sec><sec><title>Methods</title><p>Overall, 1,110 patients with SLE from the Chinese SLE Treatment and Research Group (CSTAR) and 198 age and gender-matched individuals from the general population without self-reported SLE were invited to complete questionnaires of SWB evaluated by the satisfaction with life scale (SWLS), emotional variables assessed by the patient health questionnaire-9 (PHQ-9), and general anxiety disorder-7 (GAD-7) and related positive factors assessed by the self-esteem scale (SES), general self-efficacy scale (GESE), and Connor-Davidson resilience scale (CD-RISC). The multivariate linear regression was used to examine the relationship between clinical manifestations and SWB.</p></sec><sec><title>Results</title><p>Life satisfaction was significantly lower (<italic>p</italic> &lt; 0.001) in patients with SLE than in the general population. Active skin involvement (OR = 0.923, 95% CI = 0.868–0.981, <italic>p</italic> &lt; 0.05) was negatively associated with life satisfaction scores, and age at enrollment (OR = 1.160, 95% CI = 1.092–1.230, <italic>p</italic> &lt; 0.001) were positively associated with life satisfaction scores in the multivariate regression model. The cumulative organ damage was significantly associated with depression (OR = 1.085, 95% CI = 1.022–1.153, <italic>p</italic> &lt; 0.01) and the loss of self-esteem (OR = 1.067, 95% CI = 1.004–1.133, <italic>p</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>SWB provides useful insight into the impact of SLE on psychological health and opportunities to improve quality of life and clinical care.</p></sec>