AUTHOR=Gandhi Vivek Dipak , Shrestha Palikhe Nami , Vliagoftis Harissios 

TITLE=Protease-activated receptor-2: Role in asthma pathogenesis and utility as a biomarker of disease severity

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.954990

DOI=10.3389/fmed.2022.954990

ISSN=2296-858X

ABSTRACT=<p>PAR<sub>2</sub>, a receptor activated by serine proteases, has primarily pro-inflammatory roles in the airways and may play a role in asthma pathogenesis. PAR<sub>2</sub> exerts its effects in the lungs through activation of a variety of airway cells, but also activation of circulating immune cells. There is evidence that PAR<sub>2</sub> expression increases in asthma and other inflammatory diseases, although the regulation of PAR<sub>2</sub> expression is not fully understood. Here we review the available literature on the potential role of PAR<sub>2</sub> in asthma pathogenesis and propose a model of PAR<sub>2</sub>-mediated development of allergic sensitization. We also propose, based on our previous work, that PAR<sub>2</sub> expression on peripheral blood monocyte subsets has the potential to serve as a biomarker of asthma severity and/or control.</p>