AUTHOR=Han Ye Eun , Kim Yoon Jeon , Yang Hyun Seung , Moon Byung Gill , Lee Joo Yong , Kim June-Gone , Yoon Young Hee 

TITLE=Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.947632

DOI=10.3389/fmed.2022.947632

ISSN=2296-858X

ABSTRACT=<sec><title>Purpose</title><p>To evaluate the clinical characteristics of myopic choroidal neovascularization (mCNV) according to peripapillary atrophy (PPA) and optic disk tilt and to explore whether those myopic disk deformations are associated with the prognosis of mCNV.</p></sec><sec><title>Methods</title><p>Patients with subfoveal mCNV who received intravitreal bevacizumab injection and followed for ≥3 years were included. PPA was quantified as area of the ß-zone PPA/disk area ratio (PDR) and optic disk tilt as the tilt ratio (the longest/shortest disk diameter). We compared the clinical characteristics in terms of PDR and tilt ratio and identified the poor prognostic factors using Logistic regression and Cox proportional hazard model.</p></sec><sec><title>Results</title><p>Among 80 eyes of 80 patients, 29 (36.30%) eyes developed macular atrophy during 80.71 ± 34.76 months. PDR and tilt ratio are strongly correlated with each other (<italic>P</italic> = 0.004). Higher PDR showed significant correlations with longer axial length (<italic>P</italic> = 0.013), worse baseline and final VA (<italic>P</italic> = 0.007 and <italic>P</italic> = 0.047), and thinner subfoveal choroidal thickness (<italic>P</italic> = 0.039), while higher tilt ratio showed significant correlations only with longer axial length (<italic>P</italic> = 0.036). High PDR was also an independent risk factor for both macular atrophy (OR = 2.257, <italic>P</italic> &lt; 0.001) and poor visual outcome (HR = 1.174, <italic>P</italic> = 0.007), while high disk tilt ratio was not.</p></sec><sec><title>Conclusion</title><p>Subfoveal mCNV with higher ß-zone PPA area/disk area ratio had worse functional and structural outcomes.</p></sec>