This meta-analysis aimed to test the association of angiotensin-converting enzyme (
Public literature retrieval, publication selection, and information extraction were completed independently by two investigators. Effect-size values are expressed as odds ratios (ORs) or standardized mean differences (SMDs) with a 95% confidence interval (95% CI).
Nineteen studies (2,888 patients and 9,549 controls) fulfilled the eligibility criteria. Overall investigations demonstrated that
We provided strong meta-analytical evidence supporting the causal implication of high circulating ACE concentrations in the development of asthma.